LAMB3

The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq]
Full Name
laminin, beta 3
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Brown fat cell differentiationIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Involvement in disease
Epidermolysis bullosa, junctional, Herlitz type (H-JEB):
An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
Generalized atrophic benign epidermolysis bullosa (GABEB):
A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
Amelogenesis imperfecta 1A (AI1A):
A form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. The enamel may be hypoplastic, hypomineralized or both, and affected teeth may be discoloured, sensitive or prone to disintegration.
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Anti-LAMB3 antibodies

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Mouse Anti-LAMB3 Recombinant Antibody (2G10) (CBMAB-L0593-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G10
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (17/KalininB1) (CBMAB-K2099-LY)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 17/KalininB1
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1134) (CBMAB-L0609-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1134
Application*: E, IC, IH, IP, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1133) (CBMAB-L0608-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1133
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1129) (CBMAB-L0604-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1129
Application*: IH, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1128) (CBMAB-L0603-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJL-1128
Application*: IH, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (8H5) (CBMAB-L0601-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8H5
Application*: WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1127) (CBMAB-L0600-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1127
Application*: E, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (667E12) (CBMAB-L0597-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 667E12
Application*: IH, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (3A2) (CBMAB-L0596-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3A2
Application*: P, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1124) (CBMAB-L0595-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1124
Application*: WB, P
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1123) (CBMAB-L0594-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJL-1123
Application*: WB, P
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1122) (CBMAB-L0592-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1122
Application*: P, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (1H10) (CBMAB-L0591-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H10
Application*: P, WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (CBYJL-1121) (CBMAB-L0590-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1121
Application*: WB
Datasheet SDS

Mouse Anti-LAMB3 Recombinant Antibody (1D3) (CBMAB-L0589-YJ)

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Target: LAMB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D3
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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