LYVE1

Lymphatic vessel endothelial hyaluronan receptor 1 is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Full Name
Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799).
Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460).
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Glycosaminoglycan catabolic processIEA:Ensembl
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIDA:UniProtKB
Response to woundingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.
Topology
Extracellular: 20-238
Helical: 239-259
Cytoplasmic: 260-322
PTM
O-glycosylated.
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Anti-LYVE1 antibodies

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Rabbit Anti-LYVE1 Recombinant Antibody (
11C11) (V2LY-0725-LY1515)

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Target: LYVE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11C11
Application*: E, IF, F
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-605) (CBMAB-L0506-YC)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCL-605
Application*: E, WB
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-604) (CBMAB-L0505-YC)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-604
Application*: F
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYCL-602) (CBMAB-L0503-YC)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCL-602
Application*: E, WB
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2460) (CBMAB-L2832-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2460
Application*: WB, P
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2459) (CBMAB-L2831-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2459
Application*: WB
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (ALY7) (CBMAB-L2830-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: ALY7
Application*: FC, IC, IF, C
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2457) (CBMAB-L2828-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJL-2457
Application*: FC
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (CBYJL-2456) (CBMAB-L2827-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2456
Application*: IH, WB
Datasheet SDS

Rat Anti-Lyve1 Recombinant Antibody (14-4) (CBMAB-L2826-YJ)

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Target: Lyve1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 14-4
Application*: FC, C
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2267) (CBMAB-L2531-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-2267
Application*: WB
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2265) (CBMAB-L2529-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2265
Application*: E
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2262) (CBMAB-L2525-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2262
Application*: F
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2261) (CBMAB-L2524-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2261
Application*: B
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (4G1) (CBMAB-L2523-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4G1
Application*: WB, F, E
Datasheet SDS

Rabbit Anti-LYVE1 Recombinant Antibody (4D17) (CBMAB-L2522-YJ)

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Target: LYVE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4D17
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2259) (CBMAB-L2520-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-2259
Application*: IH, WB
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (10K86) (CBMAB-L2519-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10K86
Application*: F
Datasheet SDS

Mouse Anti-LYVE1 Recombinant Antibody (CBYJL-2258) (CBMAB-L2518-YJ)

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Target: LYVE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2258
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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