MSLN

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Full Name
Mesothelin
Function
Membrane-anchored forms may play a role in cellular adhesion.

Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Biological Process
Cell adhesion Source: UniProtKB
Cell-matrix adhesion Source: GO_Central
Pancreas development Source: Ensembl
Cellular Location
Plasma membrane
Cell membrane
Golgi apparatus
Megakaryocyte-potentiating factor:
Secreted
Isoform 3:
Secreted
Involvement in disease
Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
PTM
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
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Anti-MSLN antibodies

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Rat Anti-MSLN (AA 296-580) Recombinant Antibody (CBFYM-2646) (CBMAB-M2835-FY)

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Target: MSLN
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2646
Application*: IH
Datasheet SDS

Rabbit Anti-MSLN Recombinant Antibody (D4X7M) (CBMAB-CP1591-LY)

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Target: MSLN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4X7M
Application*: WB, IP
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (1A10) (CBMAB-A5624-LY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A10
Application*: WB, E
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBT3741) (V2LY-0625-LY1333)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3741
Application*: WB
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBT4672) (V2LY-0625-LY1302)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4672
Application*: WB, F
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBT4474) (V2LY-0625-LY1301)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4474
Application*: F
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (A1191) (CBMAB-AP12304LY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1191
Application*: ELISA, IHC, WB
Datasheet SDS

Rabbit Anti-MSLN Monoclonal Antibody (SP74) (CBMAB-R0056-FY)

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Target: MSLN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP74
Application*: ELISA
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-2652) (CBMAB-M2841-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2652
Application*: IC, IF, C
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-2651) (CBMAB-M2840-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2651
Application*: EC, ED, F, IH, WB
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-2650) (CBMAB-M2839-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2650
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-MSLN (C-terminus) Recombinant Antibody (CBFYM-2649) (CBMAB-M2838-FY)

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Target: MSLN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2649
Application*: F, P
Datasheet SDS

Mouse Anti-MSLN (AA 464-563) Recombinant Antibody (CBFYM-2648) (CBMAB-M2837-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2648
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MSLN (AA 35-289) Recombinant Antibody (CBFYM-2645) (CBMAB-M2834-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2645
Application*: WB
Datasheet SDS

Mouse Anti-MSLN (AA 296-580) Recombinant Antibody (CBFYM-2644) (CBMAB-M2833-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2644
Application*: E, WB
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-0736) (CBMAB-M0878-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0736
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-0166) (CBMAB-M0189-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0166
Application*: E, WB
Datasheet SDS

Rat Anti-MSLN (AA 296-Gly580) Recombinant Antibody (CBFYM-0145) (CBMAB-M0166-FY)

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Target: MSLN
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0145
Application*: F
Datasheet SDS

Mouse Anti-MSLN Recombinant Antibody (CBFYM-0134) (CBMAB-M0154-FY)

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Target: MSLN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0134
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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