N6AMT1

This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.

Full Name

N-6 Adenine-Specific DNA Methyltransferase 1

Function

Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526).

Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526).

Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962).

Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526).

May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655).

It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).

Biological Process

Arsonoacetate metabolic process Source: UniProtKB
Chromatin organization Source: UniProtKB-KW
DNA methylation on adenine Source: UniProtKB
Histone lysine methylation Source: UniProtKB
Methylation Source: UniProtKB
Peptidyl-glutamine methylation Source: UniProtKB
Positive regulation of cell growth Source: MGI
Toxin metabolic process Source: UniProtKB

Cellular Location

Nucleus

PTM

Isoform 1:
Ubiquitinated, leading to its degradation by the proteasome.
Isoform 2:
Ubiquitinated, leading to its degradation by the proteasome.