NR4A1

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Full Name
Nuclear Receptor Subfamily 4 Group A Member 1
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity).
May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Biological Process
Apoptotic processIEA:Ensembl
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to fibroblast growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Endothelial cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Fat cell differentiationISS:UniProtKB
Negative regulation of cell cycleISS:UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA:Ensembl
Neurotransmitter secretion involved in regulation of skeletal muscle contractionIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of type B pancreatic cell proliferationISS:UniProtKB
Response to amphetamineIEA:Ensembl
Response to electrical stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skeletal muscle cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340).
Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950).
PTM
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.
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Anti-NR4A1 antibodies

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Mouse Anti-NR4A1 Recombinant Antibody (NR4AB9G12) (CBMAB-N3463-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NR4AB9G12
Application*: DB, IC, IF, WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (H1648) (CBMAB-N3461-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: H1648
Application*: E, IP, IO, WB
Datasheet SDS

Rabbit Anti-NR4A1 Recombinant Antibody (CBWJN-0061) (CBMAB-N3453-WJ)

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Target: NR4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJN-0061
Application*: WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (12.14) (CBMAB-N0515-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 12.14
Application*: WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (CBWJN-0654) (CBMAB-N3462-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBWJN-0654
Application*: WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (E-6) (CBMAB-N3459-WJ)

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Target: NR4A1
Host: Mouse
Specificity: Mouse, Rat
Clone: E-6
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-NR4A1 Recombinant Antibody (D63C5) (CBMAB-N3458-WJ)

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Target: NR4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D63C5
Application*: WB, IP, IF, F
Datasheet SDS

Rabbit Anti-NR4A1 Recombinant Antibody (D22G5) (CBMAB-N3457-WJ)

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Target: NR4A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D22G5
Application*: WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (C-5) (CBMAB-N3456-WJ)

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Target: NR4A1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: C-5
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (CBWJN-1537) (CBMAB-N3455-WJ)

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Target: NR4A1
Host: Mouse
Specificity: Human
Clone: CBWJN-1537
Application*: WB
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (1E10A15) (CBMAB-N3454-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E10A15
Application*: WB, IF
Datasheet SDS

Mouse Anti-NR4A1 Recombinant Antibody (CBWJN-1536) (CBMAB-N3452-WJ)

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Target: NR4A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBWJN-1536
Application*: WB
Datasheet SDS

Recombinant Anti-NR4A1 Recombinant Antibody (CBWJN-0792) (CBMAB-N0516-WJ)

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Target: NR4A1
Host: Recombinant
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0792
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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