POLR1E

POLR1E (RNA Polymerase I Subunit E) is a protein coding gene. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase I transcription factor binding.

Full Name

RNA Polymerase I Subunit E

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024).
Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024).

Biological Process

Nucleolar large rRNA transcription by RNA polymerase IManual Assertion Based On ExperimentIDA:UniProtKB
RNA polymerase I preinitiation complex assemblyManual Assertion Based On ExperimentIBA:GO_Central
Transcription elongation from RNA polymerase I promoterManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus

PTM

Acetylated at Lys-373 by CREBBP/CBP, leading to decreased RNA polymerase I transcription (PubMed:24207024).
In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024).
In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region (PubMed:24207024).