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PRMT6

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM
Full Name
protein arginine methyltransferase 6
Function
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520).
Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910).
Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460).
H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460).
Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293).
Repression of TP53 blocks cellular senescence (By similarity).
Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869).
Methylates HMGA1 (PubMed:16157300, PubMed:16159886).
Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity).
May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505).
Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity).
Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).
Biological Process
Base-excision repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular senescenceIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Histone H3-R2 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K4 methylationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-arginine methylation, to asymmetrical-dimethyl arginineManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of megakaryocyte differentiationTAS:Reactome
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of signal transduction by p53 class mediatorIEA:Ensembl
Cellular Location
Nucleus
PTM
Automethylation enhances its stability and antiretroviral activity.

Anti-PRMT6 antibodies

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Target: PRMT6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C9
Application*: IP, M
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H4
Application*: IP, M
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CB01A
Application*: ELISA, WB, IHC, ICC
Target: PRMT6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, S. cerevisiae
Clone: D5A2N
Application*: WB, IP
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C3
Application*: WB, E
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PRMT6-74
Application*: WB, IP, E, IC
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G2
Application*: WB
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C3-F1-G1
Application*: WB, P, IC, IF
Target: PRMT6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15B232
Application*: IC, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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