RBBP7

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Full Name

RB Binding Protein 7, Chromatin Remodeling Factor

Function

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Biological Process

Biological Process brain development1 PublicationIC:ComplexPortal
Biological Process cellular heat acclimationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process histone deacetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase II2 PublicationsIC:ComplexPortal
Biological Process negative regulation of transcription, DNA-templated1 PublicationIC:ComplexPortal
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription, DNA-templated1 PublicationIC:ComplexPortal
Biological Process regulation of cell fate specification1 PublicationIC:ComplexPortal
Biological Process regulation of stem cell differentiation1 PublicationIC:ComplexPortal
Biological Process regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process response to steroid hormoneIEA:Ensembl

Cellular Location

Nucleus