RIN3

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Full Name

Ras And Rab Interactor 3

Function

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

Biological Process

Biological Process endocytosis1 PublicationNAS:UniProtKB
Biological Process negative regulation of mast cell chemotaxisManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of receptor internalizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of vesicle sizeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Cytoplasmic vesicle
Early endosome
Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.