ROBO4
Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.
Full Name
ROUNDABOUT GUIDANCE RECEPTOR 4
Function
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415).
Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415).
Biological Process
Biological Process angiogenesisManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB
Cellular Location
axon
extracellular exosome
integral component of membrane
plasma membrane
extracellular exosome
integral component of membrane
plasma membrane
Involvement in disease
Aortic valve disease 3 (AOVD3):
A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. AOVD3 features are bicuspid aortic valve, aortic valve stenosis, and ascending aortic aneurysm. Some patients have atrial septal defects. AOVD3 inheritance is autosomal dominant with incomplete penetrance.
A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. AOVD3 features are bicuspid aortic valve, aortic valve stenosis, and ascending aortic aneurysm. Some patients have atrial septal defects. AOVD3 inheritance is autosomal dominant with incomplete penetrance.
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Anti-ROBO4 antibodies
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CompareTarget: ROBO4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-3095
Application*: E
Target: ROBO4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-3094
Application*: E
Target: ROBO4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 274914
Application*: F
Target: ROBO4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 265721
Application*: WB, F, MC
Target: ROBO4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 265703
Application*: WB, F, MC
Target: ROBO4
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0893-37R19
Application*: E, WB, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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