Rabbit Anti-ROBO4 Recombinant Antibody (CBFYM-3095) (CBMAB-M3291-FY)

Name: Rabbit Anti-ROBO4 Recombinant Antibody (CBFYM-3095)
SKU: CBMAB-M3291-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYM-3095

Application

ELISA

Immunogen

Recombinant Mouse ROBO4 protein

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ROUNDABOUT GUIDANCE RECEPTOR 4

Introduction

Robo4 deletion led to altered HSC mobilization efficiency, revealing that inhibition of both Cxcr4- and Robo4-mediated niche interactions are necessary for efficient HSC mobilization.

Entrez Gene ID

54538

UniProt ID

Q8WZ75

Alternative Names

Roundabout Guidance Receptor 4; Magic Roundabout; Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila); Roundabout, Axon Guidance Receptor, Homolog 4; Roundabout Homolog 4, Magic Roundabout; Roundabout Homolog 4 (Drosophila); Roundabout Homolog 4; ECSM4; MRB

Function

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415).

Biological Process

Biological Process angiogenesisManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB

Cellular Location

axon
extracellular exosome
integral component of membrane
plasma membrane

Involvement in disease

Aortic valve disease 3 (AOVD3):
A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. AOVD3 features are bicuspid aortic valve, aortic valve stenosis, and ascending aortic aneurysm. Some patients have atrial septal defects. AOVD3 inheritance is autosomal dominant with incomplete penetrance.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-ROBO4 Recombinant Antibody (MM0893-37R19) (CAT#: CBMAB-1778-CN)

Mouse Recombinant ROBO4 protein, His Tag (CAT#: V2LY-0526-LY8839)

Rabbit Anti-ROBO4 Recombinant Antibody (CBFYM-3094) (CAT#: CBMAB-M3290-FY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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