SLC30A6

Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM

Full Name

solute carrier family 30 (zinc transporter), member 6

Function

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

Biological Process

Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process insulin processingTAS:Reactome
Biological Process zinc ion import into organelle1 PublicationIC:UniProtKB
Biological Process zinc ion transmembrane transportTAS:Reactome
Biological Process zinc ion transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Golgi apparatus, trans-Golgi network membrane
Found in vesicles.

Topology

Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-64
Helical: 65-85
Cytoplasmic: 86-98
Helical: 99-119
Extracellular: 120-134
Helical: 135-155
Cytoplasmic: 156-200
Helical: 201-221
Extracellular: 222-223
Helical: 224-244
Cytoplasmic: 245-461