SPRY4

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants.

Sprouty RTK Signaling Antagonist 4

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893).
Probably impairs the formation of GTP-Ras (PubMed:12027893).
Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443).
Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898).

Biological Process animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process negative regulation of ERK1 and ERK2 cascadeIEA:InterPro
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm
Cell projection, ruffle membrane
Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity).
Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898).

Hypogonadotropic hypogonadism 17 with or without anosmia (HH17):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).