SRD5A1

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).

Full Name

Steroid 5 Alpha-Reductase 1

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Biological Process

Biological Process androgen biosynthetic processTAS:Reactome
Biological Process androgen catabolic processIEA:Ensembl
Biological Process bone developmentIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process cellular response to epinephrine stimulusIEA:Ensembl
Biological Process cellular response to estradiol stimulusIEA:Ensembl
Biological Process cellular response to growth factor stimulusIEA:Ensembl
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process cellular response to starvationIEA:Ensembl
Biological Process cellular response to testosterone stimulusIEA:Ensembl
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process circadian sleep/wake cycle, REM sleepIEA:Ensembl
Biological Process diterpenoid metabolic processIEA:Ensembl
Biological Process female genitalia developmentIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process liver developmentIEA:Ensembl
Biological Process male genitalia developmentIEA:Ensembl
Biological Process male gonad developmentIEA:Ensembl
Biological Process pituitary gland developmentIEA:Ensembl
Biological Process progesterone metabolic processIEA:Ensembl
Biological Process response to estrogenIEA:Ensembl
Biological Process response to follicle-stimulating hormoneIEA:Ensembl
Biological Process response to fungicideIEA:Ensembl
Biological Process response to growth hormoneIEA:Ensembl
Biological Process response to muscle activityIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin metabolic processIEA:Ensembl
Biological Process sex determination1 PublicationNAS:ProtInc
Biological Process spinal cord developmentIEA:Ensembl
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thalamus developmentIEA:Ensembl
Biological Process urogenital system developmentIEA:Ensembl

Cellular Location

Microsome membrane
Endoplasmic reticulum membrane