STMN3

This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants.

Full Name

stathmin 3

Function

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Biological Process

Biological Process blastocyst hatchingIEA:Ensembl
Biological Process cytoplasmic microtubule organizationISS:HGNC-UCL
Biological Process microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of Rac protein signal transductionISS:HGNC-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuron projection developmentISS:HGNC-UCL
Biological Process regulation of cytoskeleton organizationISS:HGNC-UCL
Biological Process regulation of GTPase activityISS:HGNC-UCL
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Golgi apparatus
Cell projection, growth cone
Cell projection, axon
Cytoplasm, cytosol

PTM

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.