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SUMO3

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM
Full Name
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
Function
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678).
Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Biological Process
Biological Process negative regulation of DNA bindingManual Assertion Based On ExperimentIDA:CAFA
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Nucleus, PML body
PTM
Polymeric chains can be formed through Lys-11 cross-linking.
Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
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Anti-SUMO3 antibodies

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Mouse Anti-SUMO3 Recombinant Antibody (CBXS-3237) (CBMAB-S5978-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3237
Application*: E, WB
Datasheet SDS

Mouse Anti-SUMO3 Recombinant Antibody (CBXS-2355) (CBMAB-S5113-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2355
Application*: E, WB
Datasheet SDS

Rat Anti-SUMO3 Recombinant Antibody (CBXS-1975) (CBMAB-S4747-CQ)

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Target: SUMO3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1975
Application*: WB
Datasheet SDS

Rat Anti-SUMO3 Recombinant Antibody (CBXS-1820) (CBMAB-S4628-CQ)

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Target: SUMO3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1820
Application*: IC
Datasheet SDS

Rat Anti-SUMO3 Recombinant Antibody (CBXS-1819) (CBMAB-S4627-CQ)

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Target: SUMO3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1819
Application*: IC
Datasheet SDS

Rabbit Anti-SUMO3 Recombinant Antibody (CBXS-0864) (CBMAB-S3786-CQ)

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Target: SUMO3
Host: Rabbit
Specificity: Human
Clone: CBXS-0864
Application*: WB, IF
Datasheet SDS

Mouse Anti-SUMO3 Recombinant Antibody (CBXS-0863) (CBMAB-S3785-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0863
Application*: E, WB
Datasheet SDS

Mouse Anti-SUMO3 Recombinant Antibody (CBXS-0862) (CBMAB-S3784-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0862
Application*: SE, WB, E, WB
Datasheet SDS

Mouse Anti-SUMO3 Recombinant Antibody (76AT630.91.31) (CBMAB-S2890-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 76AT630.91.31
Application*: WB
Datasheet SDS

Mouse Anti-SUMO3 Recombinant Antibody (V2-365918) (CBMAB-S2855-CQ)

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Target: SUMO3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-365918
Application*: E, WB
Datasheet SDS

Rabbit Anti-SUMO3 Recombinant Antibody (1H9L17) (CBMAB-S2830-CQ)

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Target: SUMO3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1H9L17
Application*: F, IC, IF, P, WB
Datasheet SDS

Rabbit Anti-SUMO3 Recombinant Antibody (CBXS-3777) (CBMAB-S1049-CQ)

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Target: SUMO3
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-3777
Application*: WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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