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TBX6

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]
Full Name
TBX6 Gene(Protein Coding) T-Box 6
Function
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).
Biological Process
Biological Process anatomical structure morphogenesisTAS:ProtInc1 Publication
Biological Process cardiac chamber developmentIBA:GO_Central1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process central nervous system developmentIBA:GO_Central1 Publication
Biological Process heart loopingIBA:GO_Central1 Publication
Biological Process mesoderm developmentTAS:ProtInc1 Publication
Biological Process mesodermal cell fate specificationIEA:Ensembl
Biological Process negative regulation of DNA-binding transcription factor activityISS:BHF-UCL
Biological Process negative regulation of neuron maturationIEA:Ensembl
Biological Process negative regulation of neuron projection developmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process positive regulation of cell population proliferationIBA:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process signal transduction involved in regulation of gene expressionIEA:Ensembl
Biological Process somite rostral/caudal axis specificationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Spondylocostal dysostosis 5 (SCDO5):
A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations. SCDO5 inheritance can be autosomal dominant or recessive.
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Anti-TBX6 antibodies

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Mouse Anti-TBX6 Recombinant Antibody (3F6) (CBMAB-A8925-LY)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F6
Application*: SE, E
Datasheet SDS

TBX6 Matched Antibody Pair (1187) (APMAB-1187LY)

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Target: TBX6
Specificity: Human
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (3F11) (CBMAB-A8924-LY)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F11
Application*: WB, E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (2D11) (CBMAB-A8922-LY)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D11
Application*: SE, E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (1D11) (CBMAB-A8921-LY)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D11
Application*: IF, E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2175) (CBMAB-T1280-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2175
Application*: SE, E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2174) (CBMAB-T1279-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2174
Application*: E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2173) (CBMAB-T1278-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2173
Application*: E, WB
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2172) (CBMAB-T1277-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2172
Application*: E
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2171) (CBMAB-T1276-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2171
Application*: E, IF
Datasheet SDS

Mouse Anti-TBX6 Recombinant Antibody (CBYJT-2170) (CBMAB-T1275-YJ)

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Target: TBX6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2170
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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