TIRAP

Tirap functions in processes like 3'-UTR-mediated mRNA stabilization, activation of NF-kappaB-inducing kinase activity, positive regulation of ERK1 and ERK2 cascade, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-15 production.

TIRAP

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

Biological Process 3'-UTR-mediated mRNA stabilizationSource:BHF-UCL1 Publication
Biological Process activation of NF-kappaB-inducing kinase activitySource:AgBase1 Publication
Biological Process cell surface receptor signaling pathwaySource:BHF-UCL
Biological Process cellular response to bacterial lipopeptideSource:BHF-UCL
Biological Process cellular response to lipoteichoic acidSource:BHF-UCL
Biological Process defense response to Gram-positive bacteriumSource:BHF-UCL
Biological Process I-kappaB kinase/NF-kappaB signalingSource:GO_Central1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process myeloid cell differentiationSource:BHF-UCL
Biological Process positive regulation of B cell proliferationSource:BHF-UCL
Biological Process positive regulation of chemokine (C-X-C motif) ligand 1 productionSource:BHF-UCL
Biological Process positive regulation of chemokine (C-X-C motif) ligand 2 productionSource:BHF-UCL
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:BHF-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:BHF-UCL1 Publication
Biological Process positive regulation of innate immune responseSource:GO_Central1 Publication
Biological Process positive regulation of interleukin-12 productionSource:BHF-UCL
Biological Process positive regulation of interleukin-15 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-6 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of JNK cascadeSource:BHF-UCL1 Publication
Biological Process positive regulation of neutrophil chemotaxisSource:BHF-UCL
Biological Process positive regulation of NF-kappaB transcription factor activitySource:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblySource:BHF-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of toll-like receptor 3 signaling pathwaySource:BHF-UCL
Biological Process positive regulation of toll-like receptor 4 signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:BHF-UCL2 Publications
Biological Process regulation of innate immune responseSource:BHF-UCL1 Publication
Biological Process regulation of interferon-beta productionSource:BHF-UCL
Biological Process regulation of stress-activated MAPK cascadeSource:GO_Central1 Publication
Biological Process response to lipopolysaccharideSource:BHF-UCL1 Publication
Biological Process TIRAP-dependent toll-like receptor 4 signaling pathwaySource:BHF-UCL1 Publication

Cytoplasm
Cell membrane
Membrane
Colocalizes with DAB2IP at the plasma membrane.

Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.
Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.