TM9SF2

TM9SF2 is a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. TM9SF2 possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. TM9SF2 may function in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome.

Full Name

transmembrane 9 superfamily member 2

Function

In the intracellular compartments, may function as a channel or small molecule transporter.

Biological Process

Biological Process ceramide metabolic processSource:UniProtKB1 Publication
Biological Process glycosphingolipid biosynthetic processSource:UniProtKB1 Publication
Biological Process protein localization to membraneSource:GO_Central1 Publication
Biological Process regulation of heparan sulfate proteoglycan biosynthetic processSource:UniProtKB1 Publication

Cellular Location

Endosome membrane
Golgi outpost
Cytoplasm, cytoskeleton, microtubule organizing center
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.

Topology

Lumenal: 29-300
Helical: 301-321
Cytoplasmic: 322-374
Helical: 375-395
Lumenal: 396-398
Helical: 399-419
Cytoplasmic: 420-437
Helical: 438-458
Lumenal: 459-466
Helical: 467-487
Cytoplasmic: 488-522
Helical: 523-543
Lumenal: 544-554
Helical: 555-575
Cytoplasmic: 576-591
Helical: 592-612
Lumenal: 613-631
Helical: 632-652
Cytoplasmic: 653-663