TMOD2

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]

Full Name

TMOD2 Gene(Protein Coding) Tropomodulin 2

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Biological Process

Biological Process actin filament organizationSource:GO_Central1 Publication
Biological Process learning or memorySource:Ensembl
Biological Process muscle contractionSource:GO_Central1 Publication
Biological Process myofibril assemblySource:GO_Central1 Publication
Biological Process nervous system developmentSource:ProtInc1 Publication
Biological Process neuron-neuron synaptic transmissionSource:Ensembl
Biological Process pointed-end actin filament cappingSource:InterPro
Biological Process positive regulation of G protein-coupled receptor signaling pathwaySource:Ensembl

Cellular Location

Cytoplasm, cytoskeleton