UCN3

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Full Name
Urocortin 3
Function
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process cellular response to hypoxia Source:Ensembl
Biological Process cellular response to nutrient levels Source:GO_Central1 Publication
Biological Process digestion Source:InterPro
Biological Process hormone-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of insulin secretion Source:Ensembl
Biological Process positive regulation of membrane potential Source:Ensembl
Biological Process response to corticosterone Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to immobilization stress Source:Ensembl
Biological Process response to starvation Source:Ensembl
Cellular Location
Secreted
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Anti-UCN3 antibodies

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Human UCN3 ELISA Kit (V2LY-0626-LY1906)

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Target: UCN3
Sensitivity: 0.0016 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-UCN3 Recombinant Antibody (13j95) (CBMAB-C4498-CN)

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Target: UCN3
Host: Mouse
Specificity: Human
Clone: 13j95
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-UCN3 Recombinant Antibody (CBCNC-113) (CBMAB-C1046-CN)

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Target: UCN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-113
Application*: ICC, P, E, WB
Datasheet SDS

Mouse Anti-UCN3 Recombinant Antibody (CBCNC-109) (CBMAB-C1023-CN)

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Target: UCN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-109
Application*: E, WB
Datasheet SDS

Mouse Anti-UCN3 Recombinant Antibody (CBXS-0936) (CBMAB-S3850-CQ)

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Target: UCN3
Host: Mouse
Specificity: Rat
Clone: CBXS-0936
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-UCN3 Recombinant Antibody (CBXS-0935) (CBMAB-S3849-CQ)

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Target: UCN3
Host: Mouse
Specificity: Human
Clone: CBXS-0935
Application*: WB, IC, P, C, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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