UCN3

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

Full Name

Urocortin 3

Function

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process cellular response to hypoxia Source:Ensembl
Biological Process cellular response to nutrient levels Source:GO_Central1 Publication
Biological Process digestion Source:InterPro
Biological Process hormone-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of insulin secretion Source:Ensembl
Biological Process positive regulation of membrane potential Source:Ensembl
Biological Process response to corticosterone Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to immobilization stress Source:Ensembl
Biological Process response to starvation Source:Ensembl

Cellular Location

Secreted