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UCN3

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Full Name
Urocortin 3
Function
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process cellular response to hypoxia Source:Ensembl
Biological Process cellular response to nutrient levels Source:GO_Central1 Publication
Biological Process digestion Source:InterPro
Biological Process hormone-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of insulin secretion Source:Ensembl
Biological Process positive regulation of membrane potential Source:Ensembl
Biological Process response to corticosterone Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to immobilization stress Source:Ensembl
Biological Process response to starvation Source:Ensembl
Cellular Location
Secreted

Anti-UCN3 antibodies

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Target: UCN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-109
Application*: E, WB
Target: UCN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-113
Application*: ICC, P, E, WB
Target: UCN3
Host: Mouse
Specificity: Human
Clone: 13j95
Application*: E, IF, IH, WB
Target: UCN3
Host: Mouse
Specificity: Human
Clone: CBXS-0935
Application*: WB, IC, P, C, E
Target: UCN3
Host: Mouse
Specificity: Rat
Clone: CBXS-0936
Application*: WB, IC, P, C, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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