WAPL

WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are Mitotic Telophase/Cytokinesis and CDK-mediated phosphorylation and removal of Cdc6.

Full Name

WAPL Cohesin Release Factor

Function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process negative regulation of chromatin binding Source:UniProtKB2 Publications
Biological Process negative regulation of DNA replication Source:UniProtKB1 Publication
Biological Process negative regulation of sister chromatid cohesion Source:UniProtKB3 Publications
Biological Process protein localization to chromatin Source:UniProtKB1 Publication
Biological Process regulation of chromosome condensation Source:GO_Central1 Publication
Biological Process regulation of cohesin loading Source:UniProtKB1 Publication

Cellular Location

Isoform 2
Nucleus
Nucleus
Chromosome
Cytoplasm
Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.