Rabbit Anti-WAPL Recombinant Antibody (D9J1U) (CBMAB-CP3006-LY)

Name: Rabbit Anti-WAPL Recombinant Antibody (D9J1U)
SKU: CBMAB-CP3006-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D9J1U

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human WAPL protein.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

WAPL Cohesin Release Factor

Introduction

WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are Mitotic Telophase/Cytokinesis and CDK-mediated phosphorylation and removal of Cdc6.

Entrez Gene ID

Human	23063
Mouse	218914
Rat	290577

UniProt ID

Human	Q7Z5K2
Mouse	Q65Z40
Rat	D4ADT3

Alternative Names

WAPL Cohesin Release Factor; KIAA0261; Friend Of EBNA2 Protein; WAPAL; FOE; Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2); Wings Apart-Like Homolog (Drosophila); Wings Apart-Like Protein Homolog; Friend Of EBNA2;

Function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process negative regulation of chromatin binding Source:UniProtKB2 Publications
Biological Process negative regulation of DNA replication Source:UniProtKB1 Publication
Biological Process negative regulation of sister chromatid cohesion Source:UniProtKB3 Publications
Biological Process protein localization to chromatin Source:UniProtKB1 Publication
Biological Process regulation of chromosome condensation Source:GO_Central1 Publication
Biological Process regulation of cohesin loading Source:UniProtKB1 Publication

Cellular Location

Isoform 2
Nucleus
Nucleus
Chromosome
Cytoplasm
Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-WAPL Recombinant Antibody (2B3) (CAT#: CBMAB-A4677-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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