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Mouse Anti-WAPL Recombinant Antibody (2B3) (CBMAB-A4677-LY)

The product is antibody recognizes KIAA0261. The antibody 2B3 immunoassay techniques such as: WB, ELISA.
See all WAPL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
KIAA0261 (AAH17393, 1 a.a. ~ 402 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WAPL Cohesin Release Factor
Entrez Gene ID
23063
UniProt ID
Q7Z5K2
Alternative Names
FOE; KIAA0261; WAPL
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process negative regulation of chromatin binding Source:UniProtKB2 Publications
Biological Process negative regulation of DNA replication Source:UniProtKB1 Publication
Biological Process negative regulation of sister chromatid cohesion Source:UniProtKB3 Publications
Biological Process protein localization to chromatin Source:UniProtKB1 Publication
Biological Process regulation of chromosome condensation Source:GO_Central1 Publication
Biological Process regulation of cohesin loading Source:UniProtKB1 Publication
Cellular Location
Isoform 2
Nucleus
Nucleus
Chromosome
Cytoplasm
Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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