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ZYX

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Full Name
Zyxin
Function
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesion1 PublicationIC:UniProtKB
Cellular response to interferon-gammaIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of inflammatory responseIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Cell junction, focal adhesion
Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
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Anti-ZYX antibodies

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Mouse Anti-ZYX Recombinant Antibody (2D1) (CBMAB-Z0810-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 2D1
Application*: E, P, WB
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CF477) (CBMAB-FT033LY)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF477
Application*: ELISA, WB, IHC, IF
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-316) (CBMAB-Z0811-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJZ-316
Application*: E, WB
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (2C10-4A7) (CBMAB-Z0809-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C10-4A7
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CL2502) (CBMAB-Z0808-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CL2502
Application*: IH, IC, P
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-313) (CBMAB-Z0807-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJZ-313
Application*: E, WB
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (692624) (CBMAB-Z0806-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 692624
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-314) (CBMAB-Z0805-WJ)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Dog, Frog, Human, Mouse, Rat
Clone: CBWJZ-314
Application*: WB, IF
Datasheet SDS

Mouse Anti-ZYX Recombinant Antibody (CBFYE-1696) (CBMAB-E2371-FY)

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Target: ZYX
Host: Mouse
Specificity: Human
Clone: CBFYE-1696
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-ZYX Monoclonal Antibody (ZOL301) (CBMAB-1727-YC)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: ZOL301
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-ZYX Monoclonal Antibody (Y48C) (CBMAB-1725-YC)

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Target: ZYX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Y48C
Application*: F, IC, IF, WB
Datasheet SDS

Rabbit Anti-ZYX (Phosphorylated S142/S143) Recombinant Antibody (D1E8) (PTM-CBMAB-0575LY)

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Target: ZYX
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Dog
Clone: D1E8
Application*: WB, IP
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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