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ZYX

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Full Name

Zyxin

Function

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesion1 PublicationIC:UniProtKB
Cellular response to interferon-gammaIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of inflammatory responseIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Cell junction, focal adhesion
Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

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Anti-ZYX antibodies

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Mouse Anti-ZYX Recombinant Antibody (2D1) (CBMAB-Z0810-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 2D1

Application*: E, P, WB

Mouse Anti-ZYX Recombinant Antibody (CF477) (CBMAB-FT033LY)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CF477

Application*: ELISA, WB, IHC, IF

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-316) (CBMAB-Z0811-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJZ-316

Application*: E, WB

Mouse Anti-ZYX Recombinant Antibody (2C10-4A7) (CBMAB-Z0809-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2C10-4A7

Application*: E, IF, IP, WB

Mouse Anti-ZYX Recombinant Antibody (CL2502) (CBMAB-Z0808-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CL2502

Application*: IH, IC, P

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-313) (CBMAB-Z0807-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJZ-313

Application*: E, WB

Mouse Anti-ZYX Recombinant Antibody (692624) (CBMAB-Z0806-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 692624

Application*: WB, IH, IC

Mouse Anti-ZYX Recombinant Antibody (CBWJZ-314) (CBMAB-Z0805-WJ)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Chicken, Dog, Frog, Human, Mouse, Rat

Clone: CBWJZ-314

Application*: WB, IF

Mouse Anti-ZYX Recombinant Antibody (CBFYE-1696) (CBMAB-E2371-FY)

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Target: ZYX

Host: Mouse

Specificity: Human

Clone: CBFYE-1696

Application*: WB, IC, P, C, E

Mouse Anti-ZYX Monoclonal Antibody (ZOL301) (CBMAB-1727-YC)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: ZOL301

Application*: E, IC, IF, WB

Mouse Anti-ZYX Monoclonal Antibody (Y48C) (CBMAB-1725-YC)

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Target: ZYX

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: Y48C

Application*: F, IC, IF, WB

Rabbit Anti-ZYX (Phosphorylated S142/S143) Recombinant Antibody (D1E8) (PTM-CBMAB-0575LY)

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Target: ZYX

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Dog

Clone: D1E8

Application*: WB, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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