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Mouse Anti-APBB1IP Recombinant Antibody (7E7A3) (CBMAB-1086-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
7E7A3
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Immunogen
Purified recombinant fragment of human APBB1IP (AA: 1-151) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000
FC1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein
Introduction
APBB1IP (Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein) is a Protein Coding gene. Among its related pathways are RET signaling and Oncogenic MAPK signaling. This is an important paralog of this gene is RAPH1. The protein appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. It suppresses insulin-induced promoter activities through AP1 and SRE. It also mediates Rap1-induced adhesion.
Entrez Gene ID
54518
UniProt ID
Q7Z5R6
Alternative Names
RIAM; INAG1; PREL1; RARP1
Function
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Biological Process
Positive regulation of cell adhesion Source: Ensembl
Signal transduction Source: InterPro
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Cellular Location
Cytoskeleton; Cell membrane; Lamellipodium; Focal adhesion; Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns5P and PtdIns3P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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