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Mouse Anti-BPIFB1 Recombinant Antibody (CBT2562) (V2LY-0625-LY2726)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2562
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human LPlunc1 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BPI Fold Containing Family B Member 1
Entrez Gene ID
92747
UniProt ID
Q8TDL5
Function
May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.
Biological Process
Antimicrobial humoral response Source: Reactome
Innate immune response in mucosa Source: UniProtKB
Negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
Cellular Location
Secreted
More Infomation

Jiang, X., Deng, X., Wang, J., Mo, Y., Shi, L., Wei, F., ... & Zeng, Z. (2021). BPIFB1 Inhibits Vasculogenic Mimicry Via Downregulation Of GLUT1-Mediated H3K27 Acetylation In Nasopharyngeal Carcinoma.

Li, J., Xu, P., Wang, L., Feng, M., Chen, D., Yu, X., & Lu, Y. (2020). Molecular biology of BPIFB1 and its advances in disease. Annals of translational medicine, 8(10).

Xu, Y., Tao, Z., Jiang, Y., Liu, T., & Xiang, Y. (2019). Overexpression of BPIFB1 promotes apoptosis and inhibits proliferation via the MEK/ERK signal pathway in nasopharyngeal carcinoma. International journal of clinical and experimental pathology, 12(1), 356.

De Smet, E. G., Seys, L. J., Verhamme, F. M., Vanaudenaerde, B. M., Brusselle, G. G., Bingle, C. D., & Bracke, K. R. (2018). Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD. International journal of chronic obstructive pulmonary disease, 13, 11.

Wei, F., Wu, Y., Tang, L., He, Y., Shi, L., Xiong, F., ... & Zeng, Z. (2018). BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM. British journal of cancer, 118(2), 233-247.

Wei, F., Tang, L., He, Y., Wu, Y., Shi, L., Xiong, F., ... & Zeng, Z. (2018). BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression. Cell death & disease, 9(4), 1-12.

Wei, F., Wu, Y., Tang, L., He, Y., Shi, L., Xiong, F., ... & Xiang, B. (2017). BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma through interaction with VTN and VIM. Br J Cancer.

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For research use only. Not intended for any clinical use.

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