Mouse Anti-DPEP1 Recombinant Antibody (CBCND-018) (V2LY-0425-LY813)

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Basic Information

Host Animal
Mouse
Clone
CBCND-018
Application
IF
Immunogen
Human DPCR-1 synthetic peptide.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
dipeptidase
Entrez Gene ID
UniProt ID
Function
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408).

Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity).

Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).

Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
Biological Process
Antibiotic metabolic process Source: UniProtKB
Cellular lactam catabolic process Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Glutathione catabolic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Homocysteine metabolic process Source: UniProtKB
Inflammatory response Source: Ensembl
Leukotriene metabolic process Source: Ensembl
Lipid metabolic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Neutrophil chemotaxis Source: Ensembl
Cellular Location
Apical cell membrane; Microvillus membrane. Brush border membrane.

Lau, A., Rahn, J. J., Chappellaz, M., Chung, H., Benediktsson, H., Bihan, D., ... & Muruve, D. A. (2022). Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Science advances, 8(5), eabm0142.

von Mässenhausen, A., Zamora Gonzalez, N., Maremonti, F., Belavgeni, A., Tonnus, W., Meyer, C., ... & Linkermann, A. (2022). Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion. Science advances, 8(5), eabl8920.

Guan, Y., Liang, X., Ma, Z., Hu, H., Liu, H., Miao, Z., ... & Susztak, K. (2021). A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nature communications, 12(1), 1-17.

Zhang, Z., Mei, Y., Feng, M., Wang, C., Yang, P., & Tian, R. (2021). The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis. International Journal of Rheumatic Diseases, 24(9), 1192-1199.

Liu, Q., Deng, J., Yang, C., Wang, Y., Shen, Y., Zhang, H., ... & Jin, J. (2020). DPEP1 promotes the proliferation of colon cancer cells via the DPEP1/MYC feedback loop regulation. Biochemical and Biophysical Research Communications, 532(4), 520-527.

Choudhury, S. R., Babes, L., Rahn, J. J., Ahn, B. Y., Goring, K. A. R., King, J. C., ... & Senger, D. L. (2019). Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver. Cell, 178(5), 1205-1221.

Cui, X., Liu, X., Han, Q., Zhu, J., Li, J., Ren, Z., ... & Dong, G. (2019). DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. Cell death & disease, 10(10), 1-16.

Tachibana, K., Saito, M., Imai, J. I., Ito, E., Yanagisawa, Y., Honma, R., ... & Takenoshita, S. (2017). Clinicopathological examination of dipeptidase 1 expression in colorectal cancer. Biomedical Reports, 6(4), 423-428.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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