DPEP1

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene.

Full Name

dipeptidase

Function

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408).

Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity).

Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).

Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.

Biological Process

Antibiotic metabolic process Source: UniProtKB
Cellular lactam catabolic process Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Glutathione catabolic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Homocysteine metabolic process Source: UniProtKB
Inflammatory response Source: Ensembl
Leukotriene metabolic process Source: Ensembl
Lipid metabolic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Neutrophil chemotaxis Source: Ensembl

Cellular Location

Apical cell membrane; Microvillus membrane. Brush border membrane.