Mouse Anti-DPEP1 Recombinant Antibody (CBCND-018) (CBMAB-R0505-CN)

Name: Mouse Anti-DPEP1 Recombinant Antibody (CBCND-018)
SKU: CBMAB-R0505-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCND-018

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Dipeptidase 1, Renal

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

dipeptidase

Introduction

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

Entrez Gene ID

1800

UniProt ID

P16444

Alternative Names

Dipeptidase 1; Microsomal Dipeptidase; Dipeptidase 1 (Renal); Dehydropeptidase-I; Renal Dipeptidase; EC 3.4.13.19;

Function

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408).

Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity).

Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).

Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.

Biological Process

Antibiotic metabolic process Source: UniProtKB
Cellular lactam catabolic process Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to nitric oxide Source: UniProtKB
Glutathione catabolic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Homocysteine metabolic process Source: UniProtKB
Inflammatory response Source: Ensembl
Leukotriene metabolic process Source: Ensembl
Lipid metabolic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Neutrophil chemotaxis Source: Ensembl

Cellular Location

Apical cell membrane; Microvillus membrane. Brush border membrane.

Lau, A., Rahn, J. J., Chappellaz, M., Chung, H., Benediktsson, H., Bihan, D., ... & Muruve, D. A. (2022). Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Science advances, 8(5), eabm0142.

von Mässenhausen, A., Zamora Gonzalez, N., Maremonti, F., Belavgeni, A., Tonnus, W., Meyer, C., ... & Linkermann, A. (2022). Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion. Science advances, 8(5), eabl8920.

Guan, Y., Liang, X., Ma, Z., Hu, H., Liu, H., Miao, Z., ... & Susztak, K. (2021). A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nature communications, 12(1), 1-17.

Zhang, Z., Mei, Y., Feng, M., Wang, C., Yang, P., & Tian, R. (2021). The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis. International Journal of Rheumatic Diseases, 24(9), 1192-1199.

Liu, Q., Deng, J., Yang, C., Wang, Y., Shen, Y., Zhang, H., ... & Jin, J. (2020). DPEP1 promotes the proliferation of colon cancer cells via the DPEP1/MYC feedback loop regulation. Biochemical and Biophysical Research Communications, 532(4), 520-527.

Choudhury, S. R., Babes, L., Rahn, J. J., Ahn, B. Y., Goring, K. A. R., King, J. C., ... & Senger, D. L. (2019). Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver. Cell, 178(5), 1205-1221.

Cui, X., Liu, X., Han, Q., Zhu, J., Li, J., Ren, Z., ... & Dong, G. (2019). DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway. Cell death & disease, 10(10), 1-16.

Tachibana, K., Saito, M., Imai, J. I., Ito, E., Yanagisawa, Y., Honma, R., ... & Takenoshita, S. (2017). Clinicopathological examination of dipeptidase 1 expression in colorectal cancer. Biomedical Reports, 6(4), 423-428.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DPEP1 Recombinant Antibody (CBCND-018) (CAT#: V2LY-0425-LY813)

Related Products

Mouse Anti-DPEP1 Recombinant Antibody (CBCND-018) (CAT#: V2LY-0425-LY813)

Isotype control

For research use only. Not intended for any clinical use.

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