Mouse Anti-DTYMK Recombinant Antibody (2G11) (CBMAB-D1865-YC)

Name: Mouse Anti-DTYMK Recombinant Antibody (2G11)
SKU: CBMAB-D1865-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G11

Application

ELISA, WB

Immunogen

DTYMK (NP_036277, 103 a.a. ~ 212 a.a) partial recombinant protein with GST tag. The immunogen sequence: VAFTGAKENF SLDWCKQPDV GLPKPDLVLF LQLQLADAAK RGAFGHERYE NGAFQERALR CFHQLMKDTT LNWKMVDASK SIEAVHEDIR VLSEDAIRTA TEKPLGELWK

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

deoxythymidylate kinase (thymidylate kinase)

Introduction

DTYMK (Deoxythymidylate Kinase) is a protein coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. It has proved that the protein has kinase activity and thymidylate kinase activity.

Entrez Gene ID

1841

UniProt ID

P23919

Alternative Names

Deoxythymidylate Kinase; DTMP Kinase; Deoxythymidylate Kinase (Thymidylate Kinase); CDC8; TMPK; TYMK;

Research Area

Catalyzes the conversion of dTMP to dTDP.

Biological Process

Cellular response to growth factor stimulus Source: Ensembl
dTDP biosynthetic process Source: GO_Central
dTTP biosynthetic process Source: GO_Central
dUDP biosynthetic process Source: GO_Central
Myoblast differentiation Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to estrogen Source: Ensembl
Thymidine biosynthetic process Source: GO_Central

Cellular Location

Cytosol; Mitochondrial intermembrane space; Mitochondrial matrix; Mitochondrion; Nucleus; Cytoplasm

Vanoevelen, J. M., Bierau, J., Grashorn, J. C., Lambrichs, E., Kamsteeg, E. J., Bok, L. A., ... & Stumpel, C. T. (2022). DTYMK is essential for genome integrity and neuronal survival. Acta neuropathologica, 143(2), 245-262.

Sun, F., Liu, Y., Gong, T., Pan, Q., Xiang, T., Zhao, J., ... & Xia, J. (2021). Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin. Cell death & disease, 12(12), 1-9.

Guo, Y., Luo, W., Huang, S., Zhao, W., Chen, H., Ma, Y., ... & Chen, M. (2021). DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 8, 871.

He, G., Qiu, J., Liu, C., Tian, B., Cai, D., & Liu, S. (2021). MiR-148b-3p Regulates the Expression of DTYMK to Drive Hepatocellular Carcinoma Cell Proliferation and Metastasis. Frontiers in oncology, 11.

Lam, C. W., Yeung, W. L., Ling, T. K., Wong, K. C., & Law, C. Y. (2019). Deoxythymidylate kinase, DTYMK, is a novel gene for mitochondrial DNA depletion syndrome. Clinica Chimica Acta, 496, 93-99.

Beckley, A. (2019). Investigation of deoxythymidylate kinase (dTYMK) as an imaging and therapeutic target (Doctoral dissertation, Imperial College London).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DTYMK Recombinant Antibody (2G11) (CAT#: V2LY-0425-LY1043)

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Isotype control

For research use only. Not intended for any clinical use.

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