Mouse Anti-DTYMK Recombinant Antibody (2G11) (V2LY-0425-LY1043)

Name: Mouse Anti-DTYMK Recombinant Antibody (2G11)
SKU: V2LY-0425-LY1043
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2G11

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

DTYMK (aa103-212) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

deoxythymidylate kinase (thymidylate kinase)

Entrez Gene ID

1841

UniProt ID

P23919

Research Area

Catalyzes the conversion of dTMP to dTDP.

Biological Process

Cellular response to growth factor stimulus Source: Ensembl
dTDP biosynthetic process Source: GO_Central
dTTP biosynthetic process Source: GO_Central
dUDP biosynthetic process Source: GO_Central
Myoblast differentiation Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to estrogen Source: Ensembl
Thymidine biosynthetic process Source: GO_Central

Cellular Location

Cytosol; Mitochondrial intermembrane space; Mitochondrial matrix; Mitochondrion; Nucleus; Cytoplasm

More Infomation

References

Vanoevelen, J. M., Bierau, J., Grashorn, J. C., Lambrichs, E., Kamsteeg, E. J., Bok, L. A., ... & Stumpel, C. T. (2022). DTYMK is essential for genome integrity and neuronal survival. Acta neuropathologica, 143(2), 245-262.

Sun, F., Liu, Y., Gong, T., Pan, Q., Xiang, T., Zhao, J., ... & Xia, J. (2021). Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin. Cell death & disease, 12(12), 1-9.

Guo, Y., Luo, W., Huang, S., Zhao, W., Chen, H., Ma, Y., ... & Chen, M. (2021). DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 8, 871.

He, G., Qiu, J., Liu, C., Tian, B., Cai, D., & Liu, S. (2021). MiR-148b-3p Regulates the Expression of DTYMK to Drive Hepatocellular Carcinoma Cell Proliferation and Metastasis. Frontiers in oncology, 11.

Lam, C. W., Yeung, W. L., Ling, T. K., Wong, K. C., & Law, C. Y. (2019). Deoxythymidylate kinase, DTYMK, is a novel gene for mitochondrial DNA depletion syndrome. Clinica Chimica Acta, 496, 93-99.

Beckley, A. (2019). Investigation of deoxythymidylate kinase (dTYMK) as an imaging and therapeutic target (Doctoral dissertation, Imperial College London).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DTYMK Recombinant Antibody (2G11)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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