Mouse Anti-DTYMK Recombinant Antibody (CBYJT-1202) (V2LY-0425-LY1045)

Name: Mouse Anti-DTYMK Recombinant Antibody (CBYJT-1202)
SKU: V2LY-0425-LY1045
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-DTYMK Recombinant Antibody (CBYJT-1202) (V2LY-0425-LY1045-1) in WB

Comparison by western blot of the expression levels of different pyrimidine metabolism enzymes in parental HAP1 WT and DCTPP1-KO cells. Anti-α-tubulin was used to normalize protein levels. ...View More

Martínez-Arribas, B., Requena, C. E., Pérez-Moreno, G., Ruíz-Pérez, L. M., Vidal, A. E., & González-Pacanowska, D. (2020). DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools. Cellular and Molecular Life Sciences, 77, 1645-1660.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-1202

Application

WB, IP, IF, ELISA

Immunogen

Full length DTYMK of human DTYMK.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

deoxythymidylate kinase (thymidylate kinase)

Entrez Gene ID

1841

UniProt ID

P23919

Research Area

Catalyzes the conversion of dTMP to dTDP.

Biological Process

Cellular response to growth factor stimulus Source: Ensembl
dTDP biosynthetic process Source: GO_Central
dTTP biosynthetic process Source: GO_Central
dUDP biosynthetic process Source: GO_Central
Myoblast differentiation Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to estrogen Source: Ensembl
Thymidine biosynthetic process Source: GO_Central

Cellular Location

Cytosol; Mitochondrial intermembrane space; Mitochondrial matrix; Mitochondrion; Nucleus; Cytoplasm

Vanoevelen, J. M., Bierau, J., Grashorn, J. C., Lambrichs, E., Kamsteeg, E. J., Bok, L. A., ... & Stumpel, C. T. (2022). DTYMK is essential for genome integrity and neuronal survival. Acta neuropathologica, 143(2), 245-262.

Sun, F., Liu, Y., Gong, T., Pan, Q., Xiang, T., Zhao, J., ... & Xia, J. (2021). Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin. Cell death & disease, 12(12), 1-9.

Guo, Y., Luo, W., Huang, S., Zhao, W., Chen, H., Ma, Y., ... & Chen, M. (2021). DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 8, 871.

He, G., Qiu, J., Liu, C., Tian, B., Cai, D., & Liu, S. (2021). MiR-148b-3p Regulates the Expression of DTYMK to Drive Hepatocellular Carcinoma Cell Proliferation and Metastasis. Frontiers in oncology, 11.

Lam, C. W., Yeung, W. L., Ling, T. K., Wong, K. C., & Law, C. Y. (2019). Deoxythymidylate kinase, DTYMK, is a novel gene for mitochondrial DNA depletion syndrome. Clinica Chimica Acta, 496, 93-99.

Beckley, A. (2019). Investigation of deoxythymidylate kinase (dTYMK) as an imaging and therapeutic target (Doctoral dissertation, Imperial College London).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DTYMK Recombinant Antibody (CBYJT-1202) (CAT#: CBMAB-T0216-YJ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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