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Mouse Anti-FcRL5 Recombinant Antibody (AG72) (V2LY-0524-LY23)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
AG72
Antibody Isotype
IgG2a, κ
Application
Blocking, FC, In Vivo, IP

Basic Information

Immunogen
Cells transfected with Human FcRL5.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc Receptor Like 5
Entrez Gene ID
83416
UniProt ID
Q96RD9
Alternative Names
Fc Receptor Like 5; Immune Receptor Translocation-Associated Protein 2; Fc Receptor Homolog 5; FcR-Like Protein 5; BXMAS1; FCRH5; IRTA2; Immunoglobulin Superfamily Receptor Translocation Associated 2 (IRTA2);
Research Area
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).
Topology
Extracellular: 16-851
Helical: 852-872
Cytoplasmic: 873-977
More Infomation

Ogega, C. O., Skinner, N. E., Flyak, A. I., Clark, K. E., Board, N. L., Bjorkman, P. J., ... & Bailey, J. R. (2022). B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection. PLoS pathogens, 18(1), e1010179.

Reyes, R. A., Clarke, K., Gonzales, S. J., Cantwell, A. M., Garza, R., Catano, G., ... & Bunnik, E. M. (2021). SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease. PloS one, 16(12), e0261656.

Gonzales, S. J., Bol, S., Braddom, A. E., Sullivan, R., Reyes, R. A., Ssewanyana, I., ... & Bunnik, E. M. (2021). Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria. Malaria journal, 20(1), 1-15.

Liu, H. W., Wei, D. X., He, D. W., Deng, J. Z., Zhu, J. J., Xu, K., ... & Fu, L. G. (2020). The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e920956-1.

Gu, Z., Shen, Y., Tang, X. Y., Ke, X., Yao, H. B., Hong, S. L., & Kang, H. Y. (2019). Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population. International journal of pediatric otorhinolaryngology, 120, 58-63.

Franco, A., Kraus, Z., Li, H., Seibert, N., Dement-Brown, J., & Tolnay, M. (2018). CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity. International immunology, 30(12), 569-578.

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For research use only. Not intended for any clinical use.

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