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Rabbit Anti-FCRL5 Recombinant Antibody (EG1186) (CBMAB-EN1429-LY)

The product is antibody recognizes FCRL5. The antibody EG1186 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all FCRL5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1186
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human FCRL5.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fc Receptor Like 5
Introduction
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Entrez Gene ID
83416
UniProt ID
Q96RD9
Alternative Names
Fc Receptor Like 5; Immune Receptor Translocation-Associated Protein 2; Fc Receptor Homolog 5; FcR-Like Protein 5; BXMAS1; FCRH5; IRTA2; Immunoglobulin Superfamily Receptor Translocation Associated 2 (IRTA2);
Research Area
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).
Topology
Extracellular: 16-851
Helical: 852-872
Cytoplasmic: 873-977

Ogega, C. O., Skinner, N. E., Flyak, A. I., Clark, K. E., Board, N. L., Bjorkman, P. J., ... & Bailey, J. R. (2022). B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection. PLoS pathogens, 18(1), e1010179.

Reyes, R. A., Clarke, K., Gonzales, S. J., Cantwell, A. M., Garza, R., Catano, G., ... & Bunnik, E. M. (2021). SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease. PloS one, 16(12), e0261656.

Gonzales, S. J., Bol, S., Braddom, A. E., Sullivan, R., Reyes, R. A., Ssewanyana, I., ... & Bunnik, E. M. (2021). Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria. Malaria journal, 20(1), 1-15.

Liu, H. W., Wei, D. X., He, D. W., Deng, J. Z., Zhu, J. J., Xu, K., ... & Fu, L. G. (2020). The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e920956-1.

Gu, Z., Shen, Y., Tang, X. Y., Ke, X., Yao, H. B., Hong, S. L., & Kang, H. Y. (2019). Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population. International journal of pediatric otorhinolaryngology, 120, 58-63.

Franco, A., Kraus, Z., Li, H., Seibert, N., Dement-Brown, J., & Tolnay, M. (2018). CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity. International immunology, 30(12), 569-578.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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