Mouse Anti-GCM1 Recombinant Antibody (CBLG1-813) (CBMAB-G2660-LY)

Name: Mouse Anti-GCM1 Recombinant Antibody (CBLG1-813)
SKU: CBMAB-G2660-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBLG1-813

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glial Cells Missing Homolog 1

Introduction

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

Entrez Gene ID

8521

UniProt ID

Q9NP62

Alternative Names

Glial Cells Missing Homolog 1; GCM Motif Protein 1; HGCMa; GCMA; Glial Cells Missing (Drosophila) Homolog A; Glial Cells Missing Homolog 1 (Drosophila); Chorion-Specific Transcription Factor GCMa;

Function

Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678).

Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267).

Binds to the SYDE1 promoter (PubMed:27917469).

Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Astrocyte fate commitment Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Cell differentiation involved in embryonic placenta development Source: GO_Central
Gliogenesis Source: GO_Central
Positive regulation of syncytium formation by plasma membrane fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell differentiation involved in embryonic placenta development Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus

PTM

Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GCM1 Matched Antibody Pair (477) (CAT#: APMAB-477LY)

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Mouse Anti-GCM1 Recombinant Antibody (3D2) (CAT#: CBMAB-G2651-LY)

Mouse Anti-GCM1 Recombinant Antibody (CBLG1-812) (CAT#: CBMAB-G2659-LY)

Mouse Anti-GCM1 Recombinant Antibody (3G5) (CAT#: CBMAB-G2653-LY)

GCM1 Matched Antibody Pair (477) (CAT#: APMAB-477LY)

Mouse Anti-GCM1 Recombinant Antibody (CBLG1-814) (CAT#: CBMAB-G2661-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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