GCM1

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

Glial Cells Missing Homolog 1

Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678).

Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267).

Binds to the SYDE1 promoter (PubMed:27917469).

Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).

Anatomical structure morphogenesis Source: ProtInc
Astrocyte fate commitment Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Cell differentiation involved in embryonic placenta development Source: GO_Central
Gliogenesis Source: GO_Central
Positive regulation of syncytium formation by plasma membrane fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell differentiation involved in embryonic placenta development Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB

Nucleus

Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).