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GCM1

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Full Name
Glial Cells Missing Homolog 1
Function
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678).

Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267).

Binds to the SYDE1 promoter (PubMed:27917469).

Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Astrocyte fate commitment Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Cell differentiation involved in embryonic placenta development Source: GO_Central
Gliogenesis Source: GO_Central
Positive regulation of syncytium formation by plasma membrane fusion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: MGI
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell differentiation involved in embryonic placenta development Source: UniProtKB
Regulation of transcription, DNA-templated Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
PTM
Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
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Anti-GCM1 antibodies

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GCM1 Matched Antibody Pair (477) (APMAB-477LY)

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Target: GCM1
Specificity: Human
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (CBLG1-814) (CBMAB-G2661-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-814
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (CBLG1-813) (CBMAB-G2660-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-813
Application*: WB
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (CBLG1-812) (CBMAB-G2659-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-812
Application*: E, EC, IF, WB
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (3G5) (CBMAB-G2653-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G5
Application*: E, WB
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (3D2) (CBMAB-G2651-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D2
Application*: E, WB
Datasheet SDS

Mouse Anti-GCM1 Recombinant Antibody (2E11) (CBMAB-G2650-LY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E11
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-GCM1 (AA 108-166) Recombinant Antibody (CBFYH-0295) (CBMAB-H1167-FY)

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Target: GCM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0295
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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