Mouse Anti-GPN1 Recombinant Antibody (CBLG1-1623) (CBMAB-G4604-LY)

Name: Mouse Anti-GPN1 Recombinant Antibody (CBLG1-1623)
SKU: CBMAB-G4604-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1623

Application

ELISA, IF, IHC-P, WB

Immunogen

XAB1 (AAH07451, 9 a.a. ~ 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GPN-Loop GTPase 1

Introduction

This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Entrez Gene ID

11321

UniProt ID

Q9HCN4

Alternative Names

GPN-Loop GTPase 1; RNA Polymerase II Associated Protein 4; XPA Binding Protein 1; GTPase; RNAPII-Associated Protein 4; MBD2-Interacting Protein; MBDIN; RPAP4; XAB1;

Function

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307).

May act at an RNAP assembly step prior to nuclear import (PubMed:21768307).

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375).

May be involved in nuclear localization of XPA (PubMed:11058119).

Cellular Location

Nucleus; Cytoplasm. Shuttles between the nucleus and the cytoplasm.

Liu, X., Xie, D., Hua, Y., Zeng, P., Ma, L., & Zeng, F. (2020). Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. The FASEB Journal, 34(11), 15547-15558.

Cristóbal‐Mondragón, G. R., Lara‐Chacón, B., Santiago, Á., De‐la‐Rosa, V., González‐González, R., Muñiz‐Luna, J. A., ... & Calera, M. R. (2019). FRET‐based analysis and molecular modeling of the human GPN‐loop GTP ases 1 and 3 heterodimer unveils a dominant‐negative protein complex. The FEBS Journal, 286(23), 4797-4818.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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