Mouse Anti-GPN1 Recombinant Antibody (CBYCX-104) (CBMAB-X0041-YC)

Name: Mouse Anti-GPN1 Recombinant Antibody (CBYCX-104)
SKU: CBMAB-X0041-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCX-104

Application

WB, IHC-P, ICC, IF

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GPN-Loop GTPase 1

Introduction

GPN1 is a guanosine triphosphatase enzyme, which is small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). GPN1 acts at an RNAP assembly step prior to nuclear import and forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. GPN1 may be involved in nuclear localization of XPA

Entrez Gene ID

11321

UniProt ID

Q9HCN4

Alternative Names

XAB1; MBDIN; NTPBP; RPAP4; ATPBD1A

Function

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307).

May act at an RNAP assembly step prior to nuclear import (PubMed:21768307).

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375).

May be involved in nuclear localization of XPA (PubMed:11058119).

Cellular Location

Nucleus; Cytoplasm. Shuttles between the nucleus and the cytoplasm.

Liu, X., Xie, D., Hua, Y., Zeng, P., Ma, L., & Zeng, F. (2020). Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. The FASEB Journal, 34(11), 15547-15558.

Cristóbal‐Mondragón, G. R., Lara‐Chacón, B., Santiago, Á., De‐la‐Rosa, V., González‐González, R., Muñiz‐Luna, J. A., ... & Calera, M. R. (2019). FRET‐based analysis and molecular modeling of the human GPN‐loop GTP ases 1 and 3 heterodimer unveils a dominant‐negative protein complex. The FEBS Journal, 286(23), 4797-4818.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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