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Mouse Anti-GRK3 Recombinant Antibody (497018) (CBMAB-G0803-LY)

This product is antibody recognizes GRK3. The antibody 497018 immunoassay techniques such as: WB.
See all GRK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
497018
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human GRK3, Pro469-Leu688, Accession # P35626
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor kinase 3
Introduction
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Entrez Gene ID
157
UniProt ID
P35626
Alternative Names
G Protein-Coupled Receptor Kinase 3; Adrenergic; Beta; Receptor Kinase 2; EC 2.7.11.15; Beta-ARK-2; ADRBK2; BARK2; G-Protein-Coupled Receptor Kinase 3; Beta-Adrenergic Receptor Kinase 2; EC 2.7.11;
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
Biological Process
Desensitization of G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cytosol; Plasma membrane
PTM
Ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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