Rabbit Anti-GRK3 Recombinant Antibody (EG1445) (CBMAB-EN1726-LY)

Name: Rabbit Anti-GRK3 Recombinant Antibody (EG1445)
SKU: CBMAB-EN1726-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1445

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GRK3.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor kinase 3

Introduction

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

Entrez Gene ID

Human	157
Mouse	320129
Rat	25372

UniProt ID

Human	P35626
Mouse	Q8BVT9
Rat	P26819

Alternative Names

BARK2; ADRBK2

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Biological Process

Desensitization of G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cytosol; Plasma membrane

PTM

Ubiquitinated.

Rabjohns, E. M., Rampersad, R. R., Ghosh, A., Hurst, K., Eudy, A. M., Brozowski, J. M., ... & Tarrant, T. K. (2023). Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone. Cells, 12(7), 981.

Gazdarica, M., Noda, J., Durydivka, O., Novosadova, V., Mackie, K., Pin, J. P., ... & Blahos, J. (2022). SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome. Journal of Neurochemistry, 160(6), 625-642.

Brozowski, J. M., Timoshchenko, R. G., Serafin, D. S., Allyn, B., Koontz, J., Rabjohns, E. M., ... & Tarrant, T. K. (2022). G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Stem cell research & therapy, 13(1), 37.

Ihara, S., & Touhara, K. (2018). G Protein-Coupled Receptor Kinase 3 (GRK3) in Olfaction. Olfactory Receptors: Methods and Protocols, 33-41.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-GRK3 Recombinant Antibody (CBLG1-1783) (CAT#: CBMAB-G4995-LY)

Mouse Anti-GRK3 Recombinant Antibody (497018) (CAT#: CBMAB-G0803-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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