Rabbit Anti-GRK3 Recombinant Antibody (CBLG1-1783) (CBMAB-G4995-LY)

This product is antibody recognizes GRK3. The antibody CBLG1-1783 immunoassay techniques such as: WB.
See all GRK3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

CBLG1-1783

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor kinase 3

Introduction

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	157
Mouse	320129

UniProt ID

Human	P35626
Mouse	Q8BVT9

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Biological Process

Desensitization of G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cytosol; Plasma membrane

PTM

Ubiquitinated.

References

Rabjohns, E. M., Rampersad, R. R., Ghosh, A., Hurst, K., Eudy, A. M., Brozowski, J. M., ... & Tarrant, T. K. (2023). Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone. Cells, 12(7), 981.

Gazdarica, M., Noda, J., Durydivka, O., Novosadova, V., Mackie, K., Pin, J. P., ... & Blahos, J. (2022). SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome. Journal of Neurochemistry, 160(6), 625-642.

Brozowski, J. M., Timoshchenko, R. G., Serafin, D. S., Allyn, B., Koontz, J., Rabjohns, E. M., ... & Tarrant, T. K. (2022). G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Stem cell research & therapy, 13(1), 37.

Ihara, S., & Touhara, K. (2018). G Protein-Coupled Receptor Kinase 3 (GRK3) in Olfaction. Olfactory Receptors: Methods and Protocols, 33-41.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-GRK3 Recombinant Antibody (EG1445)

Mouse Anti-GRK3 Recombinant Antibody (497018)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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