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Mouse Anti-HELLS Antibody (2A3) (CBMAB-0453-YC)

Provided herein are mouse monoclonal antibodies against Human HELLS. The antibody clone 2A3 can be used for immunoassay techniques, such as IP and MA.
See all HELLS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A3
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HELLS
Introduction
HELLS (lymphoid-specific helicase) is a lymphoid-specific helicase. HELLS is thought to be involved with cellular proliferation and may play a role in leukemogenesis.
Entrez Gene ID
3070
UniProt ID
Q9NRZ9
Alternative Names
LSH; Nbla10143; PASG; SMARCA6
Function
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to leukemia inhibitory factor Source: Ensembl
DNA methylation Source: GO_Central
DNA methylation-dependent heterochromatin assembly Source: UniProtKB
Kidney development Source: UniProtKB
Lymphocyte proliferation Source: UniProtKB
Maintenance of DNA methylation Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Pericentric heterochromatin assembly Source: UniProtKB
Cellular Location
Nucleus. Closely associated with pericentric heterochromatin.
Involvement in disease
Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4):
A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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