Sign in or Register   Sign in or Register
  |  

Mouse Anti-HELLS Recombinant Antibody (CBYJL-2057) (CBMAB-L2185-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Helicase Lymphoid Specific (HELLS). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all HELLS antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-2057
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HELLS
Introduction
HELLS is a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. HELLS is thought to be involved with cellular proliferation and may function in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been found.
Entrez Gene ID
Human3070
Mouse15201
Rat294071
UniProt ID
HumanQ9NRZ9
MouseQ60848
RatM0R3Y7
Alternative Names
LSH; ICF4; PASG; SMARCA6; Nbla10143
Function
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to leukemia inhibitory factor Source: Ensembl
DNA methylation Source: GO_Central
DNA methylation-dependent heterochromatin assembly Source: UniProtKB
Kidney development Source: UniProtKB
Lymphocyte proliferation Source: UniProtKB
Maintenance of DNA methylation Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Pericentric heterochromatin assembly Source: UniProtKB
Cellular Location
Nucleus. Closely associated with pericentric heterochromatin.
Involvement in disease
Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4):
A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-HELLS Recombinant Antibody (CBYJL-2057)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare