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Mouse Anti-MCC (AA 5-146) Recombinant Antibody (1/MCC) (CBMAB-M2033-FY)

This product is mouse antibody that recognizes MCC. The antibody 1/MCC can be used for immunoassay techniques such as: WB, IF.
See all MCC antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1/MCC
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human MCC aa. 5-146
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 5-146

Target

Full Name
Mutated In Colorectal Cancers
Introduction
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human4163
Mouse328949
Rat307449
UniProt ID
HumanP23508
MouseE9PWI3
RatF1LZS6
Alternative Names
Mutated In Colorectal Cancers; Colorectal Mutant Cancer Protein; Protein MCC; MCC1
Function
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440).

Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Biological Process
Establishment of protein localization Source: CACAO
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Signal transduction Source: ProtInc
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytoplasm
Plasma membrane
Cell membrane
Nucleus
Other locations
lamellipodium
Note: Colocalizes with actin at the leading edge of polarized cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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