MCC Matched Antibody Pair (723) (APMAB-723LY)

This antibody pair set can be used for detecting and quantifying protein level of human MCC.
See all MCC antibodies

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-MCC monoclonal antibody, 100 ug

Detection Antibody

Anti-MCC Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Alternative Names

Mutated In Colorectal Cancers; Colorectal Mutant Cancer Protein; Protein MCC; MCC1;

Entrez Gene ID

4163

UniProt ID

P23508

References

Zhou, H. M., & Zhao, L. M. (2023). Wnt signaling pathway-derived score for predicting therapeutic resistance and tumor microenvironment in lung adenocarcinoma. Frontiers in Pharmacology, 13, 1091018.

Tomaz, L. B., Liu, B. A., Meroshini, M., Ong, S. L., Tan, E. K., Tolwinski, N. S., ... & Dunn, N. R. (2022). MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation. Journal of Cell Science, 135(21), jcs259272.

Song, H., Zhuang, L., Xu, X., Shi, J., Hu, W., Liu, Z., & Shi, S. (2021). MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene. Frontiers in Medicine, 8, 777563.

Liu, Z., Wang, P., Wold, E. A., Song, Q., Zhao, C., Wang, C., & Zhou, J. (2021). Small-molecule inhibitors targeting the canonical WNT signaling pathway for the treatment of cancer. Journal of medicinal chemistry, 64(8), 4257-4288.

Oss‐Ronen, L., & Cohen, I. (2021). Epigenetic regulation and signalling pathways in Merkel cell development. Experimental Dermatology, 30(8), 1051-1064.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Alternative Versions

MCC Matched Antibody Pair (724)

Antibody Pairs

MCC Matched Antibody Pair (724)

Related Products

MCC Matched Antibody Pair (724)

Mouse Anti-MCC (AA 5-146) Recombinant Antibody (1/MCC)

Mouse Anti-MCC (AA 31-130) Recombinant Antibody (CBFYM-0477)

Mouse Anti-MCC (AA 31-130) Recombinant Antibody (CBFYM-1862)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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