MCC

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Mutated In Colorectal Cancers

Function

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440).

Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Biological Process

Establishment of protein localization Source: CACAO
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Signal transduction Source: ProtInc
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm
Plasma membrane
Cell membrane
Nucleus
Other locations
lamellipodium
Note: Colocalizes with actin at the leading edge of polarized cells.