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Mouse Anti-MYL3 Recombinant Antibody (4C2) (CBMAB-A5726-LY)

The product is antibody recognizes MYL3. The antibody 4C2 immunoassay techniques such as: WB, ELISA.
See all MYL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MYL3 (AAH09790, 1 a.a. ~ 195 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myosin Light Chain 3
Introduction
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq]
Entrez Gene ID
4634
UniProt ID
P08590
Alternative Names
CMH8; MLC1SB; MLC1V; VLC1
Function
Regulatory light chain of myosin. Does not bind calcium.
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of striated muscle contraction Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Cellular Location
Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
A band
I band
sarcomere
Involvement in disease
Cardiomyopathy, familial hypertrophic 8 (CMH8):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
PTM
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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