Mouse Anti-MYL3 Recombinant Antibody (4C2) (CBMAB-A5726-LY)

Name: Mouse Anti-MYL3 Recombinant Antibody (4C2)
SKU: CBMAB-A5726-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C2

Application

WB, ELISA

Immunogen

MYL3 (AAH09790, 1 a.a. ~ 195 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Myosin Light Chain 3

Introduction

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq]

Entrez Gene ID

4634

UniProt ID

P08590

Alternative Names

CMH8; MLC1SB; MLC1V; VLC1

Function

Regulatory light chain of myosin. Does not bind calcium.

Biological Process

Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of striated muscle contraction Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

Cellular Location

Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
A band
I band
sarcomere

Involvement in disease

Cardiomyopathy, familial hypertrophic 8 (CMH8):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.

PTM

The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.

Lee, H., Heo, Y., Kim, J. C., & Shim, Y. S. (2021). Liquid Chromatography-Tandem Mass Spectrometry for Detecting Myosin Light Chain 3 in Dry-Aged Beef. Separations, 8(11), 219.

Deng, Y., Xie, Q., Zhang, G., Li, S., Wu, Z., Ma, Z., ... & Wang, J. (2019). Slow skeletal muscle troponin T, titin and myosin light chain 3 are candidate prognostic biomarkers for Ewing's sarcoma. Oncology Letters, 18(6), 6431-6442.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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