MYL3

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Full Name
Myosin Light Chain 3
Function
Regulatory light chain of myosin. Does not bind calcium.
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of striated muscle contraction Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Cellular Location
Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
A band
I band
sarcomere
Involvement in disease
Cardiomyopathy, familial hypertrophic 8 (CMH8):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
PTM
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
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Anti-MYL3 antibodies

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Mouse Anti-MYL3 Recombinant Antibody (A1272) (CBMAB-AP12343LY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: A1272
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (7C1) (CBMAB-AO765LY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 7C1
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (3F8) (CBMAB-AO764LY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 3F8
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (4C2) (CBMAB-A5726-LY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C2
Application*: WB, E
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBCNC-668) (CBMAB-C4009-CN)

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Target: MYL3
Host: Mouse
Specificity: Human
Clone: CBCNC-668
Application*: WB, ICC, P, IH-F, E
Datasheet SDS

Mouse Anti-MYL3 (AA 39-15) Recombinant Antibody (CBFYM-2957) (CBMAB-M3152-FY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2957
Application*: WB, E, SE
Datasheet SDS

Mouse Anti-MYL3 (AA 1-195) Recombinant Antibody (CBFYM-2956) (CBMAB-M3151-FY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2956
Application*: E, WB
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBFYM-2955) (CBMAB-M3150-FY)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2955
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBT926) (V2LY-0625-LY3176)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT926
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBT927) (V2LY-0625-LY3175)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT927
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBT2355) (V2LY-0625-LY2326)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2355
Application*: WB, IH
Datasheet SDS

Mouse Anti-MYL3 Recombinant Antibody (CBT4544) (V2LY-0625-LY2325)

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Target: MYL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4544
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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