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Mouse Anti-MYL3 Recombinant Antibody (CBT4544) (V2LY-0625-LY2325)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4544
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Purified recombinant fragment of MYL3 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myosin Light Chain 3
Entrez Gene ID
4634
UniProt ID
P08590
Function
Regulatory light chain of myosin. Does not bind calcium.
Biological Process
Cardiac muscle contraction Source: BHF-UCL
Positive regulation of ATP-dependent activity Source: BHF-UCL
Regulation of striated muscle contraction Source: BHF-UCL
Regulation of the force of heart contraction Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Cellular Location
Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
A band
I band
sarcomere
Involvement in disease
Cardiomyopathy, familial hypertrophic 8 (CMH8):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
PTM
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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